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MBS1002 Biomedical Approaches

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Question:

What is the difference between linear and conformational epitopes? and why is this important?

Author: Mirte Schattorie



Answer:

Linear epitopes are epitopes that are located on the antigen in a linear fashion, while conformational epitopes are spread on the antigen, requiring a fold/3D structure of the antigen when the antibody binds this is important when you're analysing and detecting antibody-antigen reactions. e.g. in ELISA, mostly linear epitopes are used.


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