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molecular biology 1

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Question:

What's poly(A)? and what's poly(A)polymerase (PAP) and poly(A) binding protein (PABP) ?

Author: Noura Al shalan



Answer:

-poly(A) – A stretch of adenylic acid that is added to the 3′ end of mRNA following its synthesis. The main degradation enzymes work as a complex called the degradosome. -poly(A) polymerase (PAP) – The enzyme that adds the stretch of polyadenylic acid to the 3′ end of eukaryotic mRNA. It does not use a template. The modifications at both ends of mRNA protect it against degradation by exonucleases. poly(A) binding protein (PABP) – The protein that binds to the 3′ stretch of poly(A) on a eukaryotic mRNA.


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