Leucovirin rescue

Some of these adverse effects can be prevented or reversed by administering leucovorin , which is taken up more readily by normal cells than by tumor cells. Doses of leucovorin must be kept minimal to avoid possible interference with the antitumor action of MTX. The toxic effects of methotrexate on normal cells may be reduced by administration of folinic acid (leucovorin); this strategy is called leucovorin rescue. Long-term use of methotrexate has led to hepatotoxicity and to pulmonary infiltrates and fibrosis.