Halofantrine

Although its mechanism of action is unknown, this drug is active against erythrocytic (but not other) stages of all 4 human malaria species, including chloroquine-resistant falciparum. Halofantrine is not used for chemoprophylaxis because of its potential for quinidine-like cardiotoxicity (QT prolongation) and embryotoxicity. Lumefantrine, a related drug with minimal cardiotoxicity, is now used in fixed combination with artemether (Coartem) for uncomplicated falciparum malaria in many countries.