JAK-STAT pathway

JAK is activated when 2 JAK bind to one another. Once paired they become activated and this leads to recruitment and phosphorylation of STATs. JAK activates the STAT pathway. Phosphatised STAS form dimers that then binds to the promoter sequences and regulates genes in multiple key pathways. Must be turned off by negative regulator SOC’s once task is done and can be switched back on by cytokines.