Which 2 major body systems are also involved in the endocrine system?

Cardiovascular System - The cardiovascular system is the means whereby hormones are distributed throughout the body. Hormones function by producing their effects only when they attach to a suitable target receptor. Even though hormones circulate freely throughout the cardiovascular system, aside from the target receptors, the rest of the body’s systems are essentially unaffected by their presence Nervous System - The nervous system senses changes in either the internal or external environment. If the change requires a response, the nervous system interacts, via the hypothalamus, with the endocrine system, which produces the appropriate hormonal reaction