What are AU-rich elements (AREs) and iron-response element (IRE) ?

AU-rich elements (AREs) are common destabilizing elements in mammals, and are bound by a variety of proteins. Some DE-binding proteins interact with components of the decay machinery and probably recruit them for degradation. Stabilizing elements occur on some highly stable mRNAs. iron-response element (IRE) – A cis sequence found in certain mRNAs whose stability or translation is regulated by cellular iron concentration. mRNA degradation rates can be altered in response to a variety of signals.