SEARCH
You are in browse mode. You must login to use MEMORY

   Log in to start

level: Level 1 of PSORIASIS

Questions and Answers List

level questions: Level 1 of PSORIASIS

QuestionAnswer
a chronic disease that waxes and wanes. It is never cured, and it is now known to be associated with multiple comorbidities including heart disease, diabetes, and the metabolic syndrome. signs and symptoms of may subside and then flare-up again T-lymphocyte–mediated inflammatory disease resulting from a complex interplay between multiple genetic factors and environmental influences.Psoriasis
Psoriasis two peak ages of onset20 to 30 years of age. 50 to 60 years of age.
is CENTRAL to the clinical presentation of psoriasisKeratinocyte proliferation
PSORIASIS TWO MAJOR ETIOLOGICAL FACTORS:1 Genetics 2 Predisposing and precipitating factors
PSORIASIS Predisposing FACTORS1 horse-fly bite (Koebner phenomenon) 2 viral or streptococcal infection 3 use of β-adrenergic blockers
PSORIASIS Precipitating FACTORS1 NSAIDS 2 antimalarials 3 β -adrenergic blockers 4 withdrawal of corticosteroids
are responsible for the EPIDERMAL HYPERPLASIA and DERMAL INFLAMMATION that is seen in psoriasis.Interaction of dermal dendritic cells activated T cells of TH-1, TH-17 lineage with cytokines and growth factors
TYPES OF PSORIASIS1 Plaque 2 Flexural or Intertriginous 3 Seborrheic 4 Scalp 5 Acrodermatitis of Hallopeau 6 Palm or soles 7 Erythodermic 8 Guttate 9 Generalized Pustular Psoriasis
the most common type of psoriasis; 90% of Psoriasis patients chronic autoimmune condition; characterized by patches of red, inflamed skin covered with silvery scales. patches appear on the elbows, knees, scalp, and lower back, but can occur anywhere on the bodyPlaque Psoriasis
Diagnostic Tests of PSORIASIS1.Body surface area (BSA) 2.Psoriasis Area and Severity Index (PASI) 3.Physician’s Global Assessment (static PGA) 4 Quality-of-life measures such as the Dermatology Life Quality Index (DLQI) or the Short Form (SF-36) Health Survey.
Nonpharmacologic Therapy1.Stress-reduction strategies 2.Moisturizers 3.Oatmeal baths 4.Skin protection using sunscreens.
PSORIASIS Pharmacologic TherapyTopical Therapies 1 Corticosteroids (mainstay for the majority) 2 Vitamin D3 Analogues (calcipotriol (calcipotriene), calcitriol (the active metabolite of vitamin D), and tacalcitol) 3 Retinoids (Tazarotene) 4 Anthralin (direct antiproliferative effect) 5 Coal Tar (one of the earliest agents) 6 Salicylic Acid (for patients with scalp psoriasis) 7 Calcineurin Inhibitors (for atopic dermatitis)
PSORIASIS Pharmacologic Therapy 1 Phototherapies and Photochemotherapy:1.UVB 2.NB-UVB (Narrowband UVB) 3.UVA 4.PUVA (UVA + Psoralens)
PSORIASIS Pharmacologic Therapy 1 Systemic Therapies:1.Acitretin 2.Cyclosporine 3.Methotrexate