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level: Level 1

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level questions: Level 1

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Pharmacologic Therapy For severe acne1.Antiandrogens 2.Isotretinoin 3.Topical and oral antibiotics
Pharmacologic Therapy For severe acne1.Antiandrogens 2.Isotretinoin 3.Topical and oral antibiotics
Pharmacologic Therapy For severe acne1.Antiandrogens 2.Isotretinoin 3.Topical and oral antibiotics
formation of comedones, papules, pustules, nodules, and/or cysts as a result of obstruction and inflammation of pilosebaceous units develops on the face and upper trunk often affects adolescentsAcne Vulgaris
The onset of acne vulgaris during puberty occurs at a younger chronologic age more in a. girls b. boysa. girls
In puberty, acne is often more severe in __ in about 15% of cases, which is tenfold greater a. girls b. boysb. boys
ACNE VULGARIS FOUR MAJOR ETIOLOGICAL FACTORS1 Increased sebum production 2 Hormonal influences 3 Bacterial colonization of the duct with Propionibacterium acnes 4 Production of inflammation in acne sites
Increased glucocorticoid secretion =>potentiation of the effects of androgens
Foods that are perceived to exacerbate acne1 Chocolate 2 Cola drinks 3 Milk 4 Milk products
THE PATHOGENESIS OF ACNE 4 stages1.Increased follicular keratinization 2.Increased sebum production 3.Bacterial lipolysis of sebum triglycerides to free fatty acids 4.Inflammation
Acne results from this primary lesion of both noninflammatory and inflammatory acneobstructed sebaceous follicle aka microcomedone
Acne Vulgaris Pathophysiology (step by step)1 Acne results from obstructed sebaceous follicle (microcomedone) 2 Cells adhere to each other; forms dense keratinous plug 3 Sebum becomes trapped behind keratin plug 4 sebum solidifies; forms OPEN or CLOSED comedone 5 Pooling of sebum increases Anaerobic Bacterium Propionibacterium acnes; generate T cell response; results to inflammation
1 first clinically visible lesion of acne. It takes 5 months to develop. 2 plug extends to upper canal and dilates opening; either oxidized lipid and melanin (black color) or to the impacted mass of horny cells1 Closed comedone, or whitehead 2 OPEN comedone or black head
Acne that is characterized by open and closed comedones is termed as?Noninflammatory Acne
Both recruitment of polymorphs into the follicle during the inflammatory process and release of P. acnes-generated chemokines lead to what formation? Bursts into the Dermispus formation
1 Propionibacterium acnes also produces enzymes which increase the permeability of the follicular wall, leading to: 2 Nodules, and cysts and may lead to __1 Rupture, releasing keratin, hair, lipids and irritating free fatty acids into the dermis 2 scarring
TYPES OF ACNE1 Blackheads 2 Whiteheads 3 Papules 4 Pustules 5 Nodules 6 Cysts
ACNE VULGARIS Nonpharmacologic Therapy1.Cleansing 2.Proper shaving 3.Comedone extraction 4.Ultraviolet light 5.Prevention of Cosmetic Acne
Pharmacologic Therapy For mild to moderate acne1.Topical retinoids 2.Salicylic acid 3.Benzoyl peroxide 4.Sulfur 5.Resorcinol
Pharmacologic Therapy For moderate to severe acne1.Benzoyl peroxide 2 Topical antibiotics (Clindamycin/Clindamycin + Benzoyl peroxide) 3 Oral antibiotics (erythromycin, tetracycline, or minocycline) 4 Retinoids (tretinoin, adapalene, and tazarotene, and azeleic acid).
Pharmacologic Therapy For severe acne1.Antiandrogens 2.Isotretinoin 3.Topical and oral antibiotics
Pharmacologic Therapy Anti-sebum agents1 Oral Contraceptives (norgestimate + ethinyl estradiol or norethindrone acetate + ethinyl estradiol) 2.Spironolactone 3.Cyproterone Acetate 4.Oral Corticosteroids 5.Oral Isotretinoin
Pharmacologic Therapy Pharmacologic Cleansing Options:1.Medicated Soaps and Washes