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level: CARCINOGENIC AGENTS

Questions and Answers List

level questions: CARCINOGENIC AGENTS

Question	Answer
Protein of extracellular matrix	LAMININ MOLECULE
Major component of the basal lamina of the basement membrane	LAMININ MOLECULE
A protein network foundation for most organs of the body	LAMININ MOLECULE
Thin fibrous extracellular matrix that separates the internal or external surface underlying the connective tissue	LAMININ MOLECULE
Closing down or assembly of tumor cell to an organ	DISSOLUTION
Recruitment of normal cell to tumor cell	INVASION
PREDISPOSITION TO CANCER:Geographic and racial factors, e.g. cancer of the skin; prone to caucasians	Xeroderma pigmentosum
PREDISPOSITION TO CANCER:Environmental and cultural influences; Inhalation of dust leads to	lung, hepatic cancer
PREDISPOSITION TO CANCER:Environmental and cultural influences; betel nut chewing leads to	squamous cell carcinoma
PREDISPOSITION TO CANCER:Babies, toddlers, geriatric patients; Patients with low resistance	Age and childhood cancer
PREDISPOSITION TO CANCER:Cancer na namamana	Heredity
PREDISPOSITION TO CANCER:Precancerous disorder that leads to cancer	Acquired preneoplastic disorders
PREDISPOSITION TO CANCER:Precancerous disorder that leads to cancer; endometrial hyperplasia leads to	endometrial carcinoma
PREDISPOSITION TO CANCER:Precancerous disorder that leads to cancer ; leukoplakia leads to	squamous cell carcinoma
CARCINOGENIC AGENTS (CHEMICAL):anti-cancer drugs but regrettably have been documented to induce lymphoid neoplasms, leukemia, and other forms of cancer.	Direct-Acting Alkylating Agent
CARCINOGENIC AGENTS (CHEMICAL):Drug taken before chemotherapy	Direct-Acting Alkylating Agent
CARCINOGENIC AGENTS (CHEMICAL):Weak carcinogens	Direct-Acting Alkylating Agent
CARCINOGENIC AGENTS (CHEMICAL): examples of Direct-Acting Alkylating Agent	cyclophosphamide, chlorambucil, bisulfan, melphalan
CARCINOGENIC AGENTS (CHEMICAL):Most potent carcinogens	Polycyclic aromatic hydrocarbons
CARCINOGENIC AGENTS (CHEMICAL):Usually taken from cigarette smoking	Polycyclic aromatic hydrocarbons
CARCINOGENIC AGENTS (CHEMICAL): examples of Polycyclic aromatic hydrocarbons	Dihydrodiol epoxides
CARCINOGENIC AGENTS (CHEMICAL):strong electrophilic reactants and combine with nucleophilic sites in the target cells, including DNA, RNA, and proteins	Dihydrodiol epoxides
CARCINOGENIC AGENTS (CHEMICAL):Carcinogenicity of these substances were exerted mainly in the liver where the ultimate carcinogen is formed by the intermediation of the cytochrome P-450 oxygenase systems	Aromatic amines and Azo dyes
CARCINOGENIC AGENTS (CHEMICAL):Aromatic amines and Azo dyes; Leads to hepatocellular carcinoma	Acetylaminofluorene and azo dyes
CARCINOGENIC AGENTS (CHEMICAL):Leads to bladder cancer	Beta-naphthylamine
CARCINOGENIC AGENTS (CHEMICAL):Seen in aniline dye and rubber industries	Beta-naphthylamine
CARCINOGENIC AGENTS (CHEMICAL):Produced by plants and microorganisms	Naturally occuring carcinogens
CARCINOGENIC AGENTS (CHEMICAL):produced by Aspergillus flovus from improperly stored grains and peanuts	aflatoxin B1
CARCINOGENIC AGENTS (CHEMICAL):aflatoxin B1 leads to	hepatic carcinogen
CARCINOGENIC AGENTS (CHEMICAL):formed in the GI tract of humans	Nitrosamines and amides
CARCINOGENIC AGENTS (CHEMICAL):It involves the microsomal P-450 oxygenase system	Nitrosamines and amides
CARCINOGENIC AGENTS (CHEMICAL):Nitrosamines and amides; ultimate carcinogen	Alkyl diazonium ions
CARCINOGENIC AGENTS (CHEMICAL):Nitrosamines and amides; carcinogen	D-nitrosodienthanolamines
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; bronchogenic carcinomas, mesotheliomas, GI cancers	Asbestos
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; Manufacturing, building, cement products, paper products	Asbestos
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; Used primarily to make polyvinyl chloride	Vinyl chloride
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; hemangiosarcoma of liver	Vinyl chloride
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; cancer of the lungs	Chromium, nickel, and other metals
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; factories, inhalation of dust	Chromium, nickel, and other metals
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; Ingredients of beauty products	arsenic
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; skin cancer	arsenic
physical or chemical agents that changes the genetic material, usually DNA	Mutagen
CARCINOGENIC AGENTS (RADIATION):Derived from the sun	Ultraviolet Rays
CARCINOGENIC AGENTS (RADIATION):inhibition of cell division, inactivation of enzymes, induction of mutation, and sufficient dosage killing the cell	Ultraviolet Rays
CARCINOGENIC AGENTS (RADIATION):The carcinogenecity of UV light is attributed to its formation of ________ in DNA	Pyrimidine dimers
CARCINOGENIC AGENTS (RADIATION):molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactions	Pyrimidine dimers
CARCINOGENIC AGENTS (RADIATION): cause squamous cell carcinoma, basal cell carcinoma, melanocarcinoma of the skin.	Ultraviolet Rays
CARCINOGENIC AGENTS: Skin cancer was sustained by pioneers in the development of Roentgen rays	Ionizing electromagnetic and particulate radiation
CARCINOGENIC AGENTS (RADIATION): miners of radioactive elements in central Europe and Rocky mountain (USA)	Lung cancer
CARCINOGENIC AGENTS (RADIATION): Leukemia, thyroid, breast, colon, and pulmonary carcinoma- survivors of A bomb dropped in Nagasaki and Hiroshima	Ionizing electromagnetic and particulate radiation
CARCINOGENIC AGENTS: Can transform virtually all cell types in vitro and induce neoplasms in vivo in both humans and experimental animals	Radiation
ONCOGENIC VIRUSES (DNA):Wart like apperance	papilloma viruses
ONCOGENIC VIRUSES (DNA):benign epithelial tumors, papillomas of the skin	papilloma viruses
ONCOGENIC VIRUSES (DNA):can act with immune deficiency and exposure to UV light to produce malignant change	papilloma viruses
ONCOGENIC VIRUSES (DNA):Etiologic agents of benign squamous papillomas and in some cases HPV-induced benign lesions progress to ___________	squamous cell carcinomas
ONCOGENIC VIRUSES (DNA):Form of non-hodgkin's lymphoma in which cancer start in immune cells called B-cells	Epstein-Barr virus
ONCOGENIC VIRUSES (DNA):Recognized as the fastest growing human tumor	Epstein-Barr virus
ONCOGENIC VIRUSES (DNA):It infects B cells by binding to the B cell-specific receptor for the third component of complement. The infected B cells are immortalized and can be propagated indefinitely in vitro	undifferentiated nasopharyngeal carcinoma
ONCOGENIC VIRUSES (DNA):liver cancer	hepatitis B virus
ONCOGENIC VIRUSES (DNA):The virus may have acted with the regenerative activity of liver cirrhosis	hepatitis B virus
DNA viruses causes ______ transformation	neoplastic
allows complete viral replication but die upon release of newly formed virus	Permissive cells
do not allow the virus to complete its life cycle, can be transformed into neoplastic cell due to integration of viral DNA Itto chromosome.	Nonpermissive cells
one that allows a virus to circumvent its defenses and replicate; willing cells	Cell/ host
Retrovirus-induced neoplastic transformation by insertional mutagenesis. A slow transforming virus infects a normal cell and integrates next to a proto- oncogene	human T-cell leukemia virus
production of genetic mutation; Normal cells that when it is altered, becomes oncogene	insertional mutagenesis
cause increase transcription of protooncogene product	Viral promoters