SEARCH
You are in browse mode. You must login to use MEMORY

   Log in to start

level: DRUGS - Generalized Seizures

Questions and Answers List

level questions: DRUGS - Generalized Seizures

QuestionAnswer
• introduced as a "PURE PETIT MAL" drug • MOA: has an important effect on Ca2+ currents, reducing the lowthreshold current DOC for ABSENCE SEIZUREETHOSUXIMIDE • Zarontin®
• are phenylsuccimides that were developed and marketed before ethosuximide • used as ANTI-ABSENCE DRUGPhensuximide & Methsuximide - has been used for partial seizures
• also used as the free acid, Valproic Acid • MOA: blocks high-frequency firing of neurons, modifies amino acid metabolism • Very effective against ABSENCE SEIZURE and is often PREFERRED when the patient has CONCOMITANT GENERALIZED TONIC-CLONIC ATTACKS Myoclonic seizures Generalized Tonic-Clonic Seizures MANAGEMENT OF BIPOLAR DISORDER MIGRAINE PROPHYLAXISSODIUM VALPROATE • Depakene®
Therapeutic Level SODIUM VALPROATE• 50-100mcg/mL
First Oxazolidinedione former DOC for ABSENCE SEIZURE Toxicity: SedationTrimethadione
Other Drugs Used in Management of EpilepsyBENZODIAZEPINES
• given IV or rectally for STOPPING CONTINUOUS SEIZURE ACTIVITY, especially GENERALIZED TONIC-CLONIC STATUS EPILEPTICUS •BENZODIAZEPINEDIAZEPAM • Valium®
•MORE EFFECTIVE AND LONGER ACTING THAN DIAZEPAM for STATUS EPILEPTICUS •BENZODIAZEPINELORAZEPAM • Ativan®
• a long acting drug with DOCUMENTED EFFICACY against ABSENCE SEIZURE, MYOCLONIC SEIZURES and INFANTILE SPASMCLONAZEPAM • Klonopin®
used for INFANTILE SPASM AND MYOCLONIC SEIZURESNITRAZEPAM
• approved in USA as an adjunct treatment of complex partial seizures in adults • Toxicities: drowsiness and lethargyCLORAZEPATE • Tranxene®
Limitations for BZD Use• Pronounced sedative effect • Tolerance
• a DIURETIC whose main action is the INHIBITION OF CARBONIC ANHYDRASE • MOA: mild acidosis in the brainACETAZOLAMIDE • Diamox®