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level: MODE OF ACTION

Questions and Answers List

level questions: MODE OF ACTION

QuestionAnswer
Mechanism of Action of Antiseizure Drugs• Enhancement of GABAergic (inhibitory) transmission • Diminution of excitatory (usually glutamatergic) transmission • Modification of ionic conductances
Mechanism of Action PHENYTOIN• alters Na+, K+ and Ca2+ conductance, membrane potentials, and the concentrations of amino acids and the neurotransmitters norepinephrine, acetylcholine, and GABA • blocks sustained high-frequency repetitive firing of action potentials • Inhibits calcium influx across the cell membrane (inhibits glutamate release, enhances GABA release)
Mechanism of Action CARBAMAZEPINE• blocks high frequency firing of neurons through action on VG Na+ channels • decreases synaptic release of glutamate
Mechanism of Action PHENOBARBITAL• enhancement of inhibitory processes and diminution of excitatory transmission • binds to an allosteric site on the GABAA receptor, and enhances the GABA-receptor mediated current by prolonging the openings of the chloride channels
Mechanism of Action PRIMIDONEsimilar to phenytoin but converted to phenobarbital