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level: Level 1 of INFRARED

Questions and Answers List

level questions: Level 1 of INFRARED

QuestionAnswer
ELECTROMAGNETIC RADIATION ranging between __ is passed thru a sample and is absorbed by the bonds of the molecules causing them to __1) 400 cm-1 and 4000 cm-1 (2500 and 20 000 nm) 2) stretch or bend
INFRA-RED SPECTROPHOTOMETRY applications:1 Qualitative fingerprint check for the identity of raw material 2 Preliminary check for compound identity (C=O) 3 Fingerprint (8.0 to 15um, fingerprint region) test for films, coating and packaging plastics, semi-solid samples 4 Use to detect polymorphs of drugs
INFRA-RED SPECTROPHOTOMETRY Strength: Limitations:STRENGTH - Computer control of instrument means matching of the spectrum of a compound to its standard fingerprint Limitations: - Rarely used as a quantitative technique because of difficulty in sample preparation and complexity of spectra - Sample prep requires skill since sx handling can have effect on spectrum (esp Potassium bromide)
1 color of the longest wavelength of VIS region (620 -780 nm) 2 Infra (latin) means1 Red 2 below
Some drugs assayed by IR region1 Acetazolamide 2 Propoxyphene 3 Thiotepa 4 Diethyltoluamide
is most often applied for ID purposesthe MEDIUM IR region (3 – 15 µm)
– identify pure organic and inorganic compounds (exemptions: O2, N2, Cl2) - considered LESS PRECISSE for quantitative analyses (few applications) IR spectra – greater complexity of spectra compared to UV VISIR spectrometry
greater complexity of spectra compared to UV VISIR spectra
To meet the required set in the compendium, the spectrum of __ under investigation and the corresponding __ are prepared and compared w/ one another. The __ must exhibit absorption maxima and minima only at the same λ as that of ref. std.1 medicinal agent 2 USP/NF ref. std. 3 spectrum of the medicinal agent
In IR-EMS, water cannot be used as solvent because:1. it ABSORBS most of IR radiation thereby obscuring absorption by the solute 2. water could DESTROY NaCl cells which hold the sample