level: MODE OF ACTION
Questions and Answers List
level questions: MODE OF ACTION
| Question | Answer |
|---|---|
| Indirect Agonists MOA | 1. DISPLACEMENT of stored catecholamines from the adrenergic nerve ending (e.g. Tyramine) 2. INHIBITION or REUPTAKE of catecholamines already released (e.g. cocaine and tricyclic antidepressants) |
| DOPAMINE MOA | CV: ACTIVATES β-receptors of the heart causing POSITIVE INOTROPIC and CHRONOTROPIC effects; VERY HIGH DOSES: stimulates α-receptors causing VASOCONSTRICTION Renal & visceral: dilates renal & splanchic arterioles resulting to INCREASED BLOODFLOW flow to the kidneys and other viscera |
| INDIRECT-ACTING SYMPATHOMIMETICS MOA | - may enter the sympathetic nerve ending and DISPLACE stored CATECHOLAMINE transmitter (amphetamine-like or "displacers") - INHIBIT the reuptake of released transmitter by interfering with the action of NET |