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level: Mechanism of Action

Questions and Answers List

level questions: Mechanism of Action

QuestionAnswer
Atropine MOAcauses reversible (surmountable) blockade of cholinomimetic actions at muscarinic receptors
Ganglion-Blocking Drugs MOA• competitively block ganglionic nicotinic receptors
NONDEPOLARIZING BLOCKERS MOAAt LOW DOSE: competitively block ACh at the nicotinic receptor (reversed by cholinesterase inhibitors, i.e. neostigmine) At HIGH DOSE: block the ion channels of the motor endplate
DEPOLARIZING AGENT MOAAttaches to the nicotinic receptors and acts like ACh PHASE 1 & 2
DEPOLARIZING AGENT MOA PHASE 1 and 2Phase I - causes the opening of Na channel which results to depolarization of the receptor (transient twitching of the muscle or fasciculation) Phase II – continuous depolarization gives way to gradual repolarization as the Na channel closes or is blocked (flaccid paralysis)