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level: CNS Depressant MOA

Questions and Answers List

level questions: CNS Depressant MOA

QuestionAnswer
Benzodiazepine MOA1 Bind to GABA a Receptor at different allosteric sites 2 Facilitates GABA action 3 Benzodiazepine increase FREQUENCY of OPENING of the Chloride channels 4 Membrane HYPERPOLARIZATION (decrease in cell excitability) 5 CNS Depression
Barbiturates MOA1 Bind to GABA a Receptor at different allosteric sites 2 Facilitates GABA action 3 Barbiturates increase DURATION of OPENING of the Chloride channels 4 Membrane HYPERPOLARIZATION (decrease in cell excitability) 5 CNS Depression
Non Benzodiazepine MOA1 Acts on the alpha 1 subunit 2 Promote sleepiness
Anti-Manic Agents: Lithium salts MOA1 Lithium inhibits inositol monophosphatase 2 Inhibits PIP2 3 Reduced release of IP3 and DAG 4 Decreased manic episode 5 Mood stabilized