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level: DRUGS

Questions and Answers List

level questions: DRUGS

QuestionAnswer
Aminoglycosides for GI infectionsKanamycin, Neomycin, Paromomycin
Treatment for uncomplicated gonorrhea Aminoglycoside that differs chemically and microbiologicallySpectinomycin
1 It has a Deoxystreptamine structure 2 It has a Streptadine structure1 Kanamycin, Neomycin, Gentamicin, Tobramycin 2 Streptomycin
Most effective for TB, brucellosis, tularemia, Yersinia infectionsStreptomycin
For amoebic dysenteryParomomycin
Exert a Synergistic effectAminoglycoside and Beta-lactam antibiotics
Synergistic against gentamicin-sensitive P. aeruginosa1 Carbenicillin 2 Gentamicin
For Enterococcal EndocarditisPenicillin G and Streptomycin or (Gentamicin/Kanamycin)
Less toxic than streptomycin Used in abdominal surgery to avoid complications caused by bacterial flora in bowel Isolated from Streptomyces fradiae Low toxicity and hypersensitive reactions Given in oral and topical onlyNeomycin
Used in the treatment of GI infections caused by Shigella and Salmonella, E. coli Isolation from fermentation with Streptomyces spp Obtained from soil samples in Colombia Treatment of Intestinal AmebiasisParomomycin
It is used for the treatment of GI infections, such as dysentery and systemic gram negative bacillus infections caused by Kiebsiella, Proteus, Enterobacters For disinfection of GI before an operation Isolated from cultures of Streptomyces kanamyceticusKanamycin
The least toxic member of KanamycinKanamycin A
Semisynthetic aminoglycoside prepared in Japan Synthesis involves simple acetylation of the 1 amino group of the deoxystreptamine ring of Kanamycin A. Resist attack by most bacteria-inactivating enzymes Effective against bacteria that are resistance to other aminoglycosidesAmikacin
Used against urinary infections caused gram -ve and pseudomonas Obtained form Micronospora purpurea Broad spectrum, strong activity against P. aeruginosa Topical cream or ointment: skin infectionsGentamicin sulfate BN: Garamycin
Most active of the chemically related aminoglycosides called nebramycins Obtained from a strain of Streptomyces tenebravius activity against Pseudomonas, exceeding that of gentamicin to twofold to fourfoldTobramycin Sulfate 1976, BN: Nebcin
Used against gentamicin resistant pseudomonas and proteus 1-N-ethylsisomicin (Netromycin) Semisynthetic derivative prepared by reductive ethylation of sisomycin, an aminoglycoside antibiotic Obtained from Micronospora inyoensis Ethylation causes spacial hindrance against APH and ATN enzymesNetilmicin Sulfate
Its antibacterial potency and effectiveness against aminoglycoside-inactivating enzymes resemble those of gentamicinSisomycin Sulfate
Isolated form Streptomyces spectabilis Once called actinospectin, first described by Lewis and Clapp deep IM administration Interferes with binding of tRNA to ribosomes, does not cause misreading of the messenger Bacteriostatic Alternative to pen G in uncomplicated gonorrheaSpectinomycin HCl, Sterile