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Biochemistry Unit 1


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[Front]


Exothermic Reaction
[Back]


Reactants have greater amount of energy than the products (energy release)

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Exothermic Reaction
Reactants have greater amount of energy than the products (energy release)
Exothermic Reaction
Reactants have greater amount of energy than the products (energy release)
What is a cell, and its roles?
The smallest unit of structure and function of all living organisms metabolism, homeostasis and reproduction
What is the Cell Theory?
• all organisms are made up of one or more cells, • all the life functions of an organism occur within cells, • all cells come from preexisting cells. • energy flow (metabolism and biochemistry) occurs within cells, • cells contain hereditary information (DNA) • all cells are basically the same in chemical composition in organisms of similar species.
What are cells needs?
-need to get energy from their environment -need to respond to their environment -need to reproduce.
What is the structure function relationship
• A cell’s function is usually directly related to its structure
Covalent Bonds v.s Ionic bonds
Covalent bonds form between atoms that have little if any difference in electronegativity Ionic bonds form between atoms that are significantly different in electronegativity.
What are organic compounds?
Compounds that contain mainly the elements carbon and hydrogen
Mixture v.s Compound
• A compound forms when elements combine in fixed proportions and undergo a chemical reaction. • A mixture forms when substances combine in any proportion without a chemical reaction.
What is a polar molecule?
A molecule in which part of the molecule is positively charged and part of the molecule is negatively charged.
What are the properties of water?
-cohesion, the tendency for water molecules to stick together -Boiling point 100 C -Adhesion, the bonding of a water molecule to another substance
What are hydrogen bonds?
Hydrogen bonds form between positively and negatively charged parts of water molecules. They hold the water molecules together.
What is an anabolic reaction
-Body reactions that build up molecules -Water is removed from smaller molecules to make larger ones
Catabolic Reaction
-Body reactions that break down molecules -Water is used to break bonds in larger molecules to make smaller ones
Dehydration Reaction
When molecules combine to form a single, larger molecule and also a molecule of water. -Called condensation if other molecule is formed instead of water
Hydration Reaction
Adds water to an organic molecule and breaks the large molecule into smaller molecules.
Neutrilization Reaction
When an acid and base react, they form a neutral solution of water and a salt
Describe Carbohydrates
-Contains Carbon, hydrogen, oxygen -provides energy to cells, stores energy, forms body structures
Lipids
-contains carbon, hydrogen, oxygen -stores energy, forms cell membranes, carries messages
Protiens
-carbon, hydrogen, oxygen,nitrogen, sulfur -helps cells keep their shape/structure, and makes up muscles, catalyzes chemical reactions,carries messages and materials
Nucleic Acids
-Contains carbon, hydrogen, oxygen, nitrogen, phosphorus -contains instructions for proteins, passes instructions from parents to offspring, helps make proteins
Main biological function of lipids
Energy storage major structural component of cell membranes important signaling molecules.
Condensation Reactions
-Water is produced from the two molecules being bonded together -hydrolysis is opposite
Disaccharide
If two monosaccharides bond together, they form a carbohydrate called disaccharide -Simple sugar -maltose, sucrose
Redoc Reactions?
Involves transfer of one or more electrons from one reactant to another
Oxidation
Losing Electrons
Reduction
Gaining electrons
Monosaccharides
-Primary cell energy source -Short and long term energy storage -Simple sugar ex. glucose, fructose
Polysaccharides and function
-made up of many monosaccharides -complex carbs -energy storage and structural support
Examples of Polysaccharides
Starch: We break down starch for energy Glycogen: Our form of storage of energy Cellulose: Needed for digestion
Triglecerides
-Fat storage -glycerol + 3 fatty acids
Fatty Acid
Long carbon-hydrogen chain, containing carboxyl group at end
Saturated Fatty acids
-Hard to break down -saturated fatty acids can be packed together very tightly. This allows organisms to store chemical energy very densely. ex. beef, butter, cheese
Unsaturated fatty acid
-Easier to break down -essential for human health -form bended chains ex. seeds, nuts olive oil
Phospholipids
-A phosphate group replaces one of the fatty acids attached to the glycerol -major cell membrane component
What are proteins required for
Structure regulation, function of the bodies tissues and organs
What are proteins needed for
Tissue repair and construction, structural support, transport and storage -used to replace worn-out dead cells by building cell structures
Copmosition of proteins
Composed of 20 amino acid building blocks
Amino acids functional groups
-amino group carboxyl group -remainder group
Formation of protiens
-peptide bonds join individual amino acids together
Poly-peptide chain
Multiple amino acids joined by peptide bonds
Primary structure
Amino acids bond together to from polypeptide chain
Secondary Structure
Polypeptide chain coils and folds at various locations along its length
Tertiary Structure
R groups interact to permanently change the shape of chain
Quaternary Structure
2 or more polypeptides come together to form the protien
What do nucleic acids consist of
1 or 2 long chains of repeating units called nucleotides
DNA
-provides instructions for building proteins -double stranded -4 nitrogen bases (Adenine, guanine, thymine, cytosine)
RNA
-involved in the synthesis of a protein -has ribose sugar -single-stranded -Uracil instead of Thymine
Fluid mosaic model
Describes plasma membrane as a fluid combination of phospholipids, cholesterol, proteins
Plasma membrane
Forms barrier b/w cytoplasm and environment outside cell
Hydrophilic
Water loving
Hydrophobic
Water fearing
Phospholipid bilayer
-Consists of proteins, cholesterol, carbs, and cytoskeleton -opens and closes paths through cell membrane
What does a cell membrane contain
-phospholipids, cholesterol, channel protein, peripheral protein, carrier protein, glycoprotein
Simple diffusion
-Passive transport -moves with a concentration gradient (high to low) -does not require a transport protein -caused by random motion and collision of molecules
Passive transport
Transport of small molecules across the cell membrane -doesn't require energy
Facilitated diffusion
-passive transport -moves with the concentration gradient transport proteins help things pass
ATP
Active transport (uses energy) -molecules go against the concentration gradient (low to high) energizes transport protein
Endocytosis
Cell fuses with the molecule folding inwards
Exocytosis
-Used to get rid of cell waste -Take valuable materials out that cell made -large molecules released
Phagocytosis
Movement of large molecules through the membrane - uses a vesicle to swallow or expel material
Entropy
-during energy transformation, energy is lost as thermal energy Measure of tendency of system to become unorganized
Exothermic Reaction
Reactants have greater amount of energy than the products (energy released) Catabolic
Endothermic reaction
Reactants begin with less energy than products have at the end. (energy must be supplied to facilitate reaction) Anobolic
Metabolic pathways
A stepwise sequence of reactions in cells 1. Substrate converted into the product by the first enzyme in the pathway 2. product of first reaction becomes substrate for next reaction 3. sequence continues until final product is made from initial substrate
Substances involved in metabolic reaction
-Substrates (reactants) -Enzymes Cofactors -energy carriers (mainly ATP) -End products (product of reaction)
Enzymes
-protein cells used to speed up bio reactions by lowering the activation energy -position substrates into active sites
Exergonic Reaction
Energy is released products have less chemical energy than reactants requires activation energy
Endergonic
Energy must be supplied products have more chemical energy than reactants
Catalyzed Reactions
Has a catalyst which speeds up the reaction by reducing activation needed for reaction to occur
How do enzymes work
Have surface depressions called active sites which allow specific molecules to bond to the enzyme
Lock and Key Model
Molecules that have the right shape to fit the active site can attach for chemical change to occur
Induced Fit Model
-Molecules are flexible and can change shape -Function by: 1. bringing 2 substrates together and facilitating a bond to from b/w them 2. breaking substrate to produce 2 or more products
Factors affecting enzyme activity
Temperature, PH, presence of inhibitors
Competitive inhibitor
Another substance binds to the active site, preventing substrate from binding there
Non competitive inhibitor
Another substance binds to enzyme at site other than active site
Allosteric
Inhibitor binds to separate site on enzyme changing its shape either inhibiting or activating its function
Why do we need enzymes
Without enzymes, animals would not be able to break down food molecules quickly enough to provide the energy and nutrients they need to survive
Sterols
Used by body to make certain hormones sterol cholesterol is an important part of cell membranes