BIOPHARMACEUTICS: Blood flow or Perfusion Model

Binding of drug in the tissues determined the uptake

Realistic prediction but requires much information to describe the pk models, hence difficult to obtain

Determination of drug concentration is hard to achieve due to different kinetics to the flow

Question

Blood flow or Perfusion Model

Binding of drug in the tissues determined the uptake

Realistic prediction but requires much information to describe the pk models, hence difficult to obtain

Determination of drug concentration is hard to achieve due to different kinetics to the flow

LEIGHTON DWIGHT OBILLOS · Accepted Answer

Physiologic Pharmacokinetic Model

Blood flow or Perfusion Model Binding of drug in the tissues determined the uptake Realistic prediction but requires much information to describe the pk models, hence difficult to obtain Determination of drug concentration is hard to achieve due to different kinetics to the flow