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Questions and Answers List

PROSTAGLANDIN ANALOGS

level questions: Level 2

QuestionAnswer
• PGE1 • Naturally produced in tissues such as seminal vesicles & cavernous tissues, placenta and the ductus arteriosus in fetus • CA: used to treat ED and keep the PATENT DUCTUS ARTERIOSUS in neonates with congenital heart conditions until surgery is possibleALPROSTADIL
• PGE1 • CA: for CHRONIC IDIOPATHIC CONSTIPATION, opioid-induced constipation; and irritable bowel syndrome with constipation • MOA: stimulates chloride channel in the luminal cells of the intestinal epithelium, thereby increasing intestinal fluid secretionLUBIPROSTONE
• PGE1 • CYTOPROTECTIVE prostaglandin in preventing PEPTIC ULCER • Used to protect the mucosal lining of the stomach during chronic NSAID treatment by interacting with PG receptors on parietal cells within the stomach, reducing gastric acid secretion; stimulates mucus and bicarbonate production COMBINED WITH MIFEPRISTONE FOR TERMINATING EARLY PREGNANCY Off-label use: LABOR INDUCTION (increase uterine contraction by interacting with prostaglandin receptors in the uterus)MISOPROSTOL
MISOPROSTOL with __ terminates EARLY PREGNANCYMifepristone
Obstetrics to induce laborPGE2 & PGF2A
PROSTAGLANDIN F2α ANALOGS TREATMENT OF OPEN-ANGLE GLAUCOMA by binding to prostaglandin receptors thereby increasing UVEOSCLERAL OUTFLOW, reducing IOP (given OD)•Bimatoprost •Latanoprost (Xalatan) •Tafluprost •Travoprost
increases eyelash prominence, length and darkness (approved for EYELASH HYPOTRICHOSIS)Bimatoprost
Topically active PGF2A derivative used in ophthalmology to treat OPEN ANGLE GLAUCOMALatanoprost (Xalatan)
PROSTACYCLIN (PGI2) ANALOGS• Epoprostenol (pharmaceutical form of naturally occurring PGI2) • Iloprost • Treprostinil TIE
Pharmaceutical form of naturally occurring PGI2Epoprostenol
POTENT pulmonary vasodilators for PULMONARY ARTERIAL HYPERTENSIONTreprostinil