level: Level 3
Questions and Answers List
level questions: Level 3
Question | Answer |
---|---|
Antidote to Cholinergic Poisoning Mandatory antidote for SEVERE CHOLINESTERASE inhibitor poisoning | ATROPINE |
MOA: very high affinity for phosphorus atom but does not enter CNS Effects: Regenerates active AChE; can relieve skeletal muscle and plate block CA: Usual ANTIDOTE for EARLY STAGE (48hrs) cholinesterase inhibitor poisoning | PRALIDOXIME (Protopam) |
Cholinesterase Regenerator Compounds not recommended for poisoning caused by CARBAMATES | 1 Pralidoxime (PAM) and 2 Diacetylmonoxime (DAM) given IV |
apparent within 30 mins to 2 hrs after ingestion - characterized by early signs of muscarinic excess - Atropine is an effective treatment for it | Rapid Onset Type - Mushroom Poisoning |
- first symptoms: 6-12 hours after ingestion - MAJOR TOXICITY involves hepatic and renal cellular injury - Atropine is of NO USE in this form | MUSHROOM POISONING caused by Amanita phalloides, A virosa, Galerina autumnalis, G marginata MNEMONICS: GAGA |