SEARCH
You are in browse mode. You must login to use MEMORY

   Log in to start

level: not retained well

Questions and Answers List

level questions: not retained well

QuestionAnswer
implies the ability to predict the appropriate molecular structure of a drug on the basis of information about its biologic receptorRational Drug Design
Factors Influencing Bioavailability1 First-pass Hepatic Metabolism 2 Solubility of the drug 3 Chemical instability 4 Nature of the drug formulation
• Concentration of drug at the receptor site • Commonly measured in the blood (Exception for topical agents)EFFECTIVE DRUG CONCENTRATION
Metabolism (Biotransformation) May be affected by• Drug Interactions due to inducers, inhibitors, and substrates • Genetic factors • Disease states
EXCRETION; Renal elimination of drugs:– Glomerular filtration – Proximal tubular secretion – Distal tubular reabsorption